RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers

The WNT signaling pathway is commonly altered during colorectal cancer development. The E3 ubiquitin ligase, RNF43, negatively regulates the WNT signal through increased ubiquitination and subsequent degradation of the Frizzled receptor. RNF43 has recently been reported to harbor frequent truncating...

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Detalhes bibliográficos
Publicado no:Fam Cancer
Main Authors: Fennell, Lochlan J., Clendenning, Mark, McKeone, Diane M., Jamieson, Saara H., Balachandran, Samanthy, Borowsky, Jennifer, Liu, John, Kawamata, Futoshi, Bond, Catherine E., Rosty, Christophe, Burge, Matthew E., Buchanan, Daniel D., Leggett, Barbara A., Whitehall, Vicki L. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086823/
https://ncbi.nlm.nih.gov/pubmed/28573495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-017-0003-0
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