APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers

Background: WNT activation is a hallmark of colorectal cancer. BRAF mutation is present in 15% of colorectal cancers, and the role of mutations in WNT signaling regulators in this context is unclear. Here, we evaluate the mutational landscape of WNT signaling regulators in BRAF mutant cancers. Metho...

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Gepubliceerd in:Cancers (Basel)
Hoofdauteurs: Fennell, Lochlan J., Kane, Alexandra, Liu, Cheng, McKeone, Diane, Fernando, Winnie, Su, Chang, Bond, Catherine, Jamieson, Saara, Dumenil, Troy, Patch, Ann-Marie, Kazakoff, Stephen H., Pearson, John V., Waddell, Nicola, Leggett, Barbara, Whitehall, Vicki L. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7281581/
https://ncbi.nlm.nih.gov/pubmed/32384699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12051171
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