Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia

BACKGROUND: Aspirin reduces the incidence of conventional adenomas driven by APC mutation and thus colorectal cancer. The effect of aspirin on the ~20% of colorectal cancers arising via BRAF mutation is yet to be established. METHODS: Braf(V637E/+);Villin-Cre(ERT2/+) mice were allocated to a control...

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Udgivet i:Br J Cancer
Main Authors: Kane, Alexandra M., Liu, Cheng, Fennell, Lochlan J., McKeone, Diane M., Bond, Catherine E., Pollock, Pamela M., Young, Graeme, Leggett, Barbara A., Whitehall, Vicki L. J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144376/
https://ncbi.nlm.nih.gov/pubmed/33782564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-021-01339-4
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