MLH1–93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAF(V600E) mutation

BACKGROUND: Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair deficiency and the resultant cancers have a good prognosis. The remaining SSA...

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Publicado en:BMC Cancer
Main Authors: Fennell, Lochlan J., Jamieson, Saara, McKeone, Diane, Corish, Tracie, Rohdmann, Megan, Furner, Tori, Bettington, Mark, Liu, Cheng, Kawamata, Futoshi, Bond, Catherine, Van De Pols, Jolieke, Leggett, Barbara, Whitehall, Vicki
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5756376/
https://ncbi.nlm.nih.gov/pubmed/29304767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3946-5
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