Alterations in signaling pathways that accompany spontaneous transition to malignancy in a mouse model of BRAF mutant microsatellite stable colorectal cancer

The serrated neoplasia pathway gives rise to a distinct subgroup of colorectal cancers distinguished by the presence of mutant BRAF(V600E) and the CpG Island Methylator Phenotype (CIMP). BRAF mutant CRC are commonly associated with microsatellite instability, which have an excellent clinical outcome...

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Udgivet i:Neoplasia
Main Authors: Kane, Alexandra M., Fennell, Lochlan J., Liu, Cheng, Borowsky, Jennifer, McKeone, Diane M., Bond, Catherine E., Kazakoff, Stephen, Patch, Ann-Marie, Koufariotis, Lambros T., Pearson, John, Waddell, Nicola, Leggett, Barbara A., Whitehall, Vicki L.J.
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press 2020
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Original article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961716/
https://ncbi.nlm.nih.gov/pubmed/31935636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2019.12.002
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