RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers

The WNT signaling pathway is commonly altered during colorectal cancer development. The E3 ubiquitin ligase, RNF43, negatively regulates the WNT signal through increased ubiquitination and subsequent degradation of the Frizzled receptor. RNF43 has recently been reported to harbor frequent truncating...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Fam Cancer
Egile Nagusiak: Fennell, Lochlan J., Clendenning, Mark, McKeone, Diane M., Jamieson, Saara H., Balachandran, Samanthy, Borowsky, Jennifer, Liu, John, Kawamata, Futoshi, Bond, Catherine E., Rosty, Christophe, Burge, Matthew E., Buchanan, Daniel D., Leggett, Barbara A., Whitehall, Vicki L. J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086823/
https://ncbi.nlm.nih.gov/pubmed/28573495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10689-017-0003-0
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