Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading

DNA interstrand crosslinks (ICLs) are extremely cytotoxic, but the mechanism of their repair remains incompletely understood. Using Xenopus egg extracts, we previously showed that repair of a cisplatin ICL is triggered when two replication forks converge on the lesion. After CDC45/MCM2-7/GINS (CMG)...

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Vydáno v:Cell Rep
Hlavní autoři: Amunugama, Ravindra, Willcox, Smaranda, Wu, R. Alex, Abdullah, Ummi B., El-Sagheer, Afaf H., Brown, Tom, McHugh, Peter J., Griffith, Jack D., Walter, Johannes C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086610/
https://ncbi.nlm.nih.gov/pubmed/29924986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.061
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