Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading

DNA interstrand crosslinks (ICLs) are extremely cytotoxic, but the mechanism of their repair remains incompletely understood. Using Xenopus egg extracts, we previously showed that repair of a cisplatin ICL is triggered when two replication forks converge on the lesion. After CDC45/MCM2-7/GINS (CMG)...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Amunugama, Ravindra, Willcox, Smaranda, Wu, R. Alex, Abdullah, Ummi B., El-Sagheer, Afaf H., Brown, Tom, McHugh, Peter J., Griffith, Jack D., Walter, Johannes C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6086610/
https://ncbi.nlm.nih.gov/pubmed/29924986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.05.061
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