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The DNA replication fork suppresses CMG unloading from chromatin before termination
When converging replication forks meet during replication termination, the CMG (Cdc45–MCM2–7–GINS) helicase is polyubiquitylated by CRL2(Lrr1) and unloaded from chromatin by the p97 ATPase. Here, we investigate the signal that triggers CMG unloading in Xenopus egg extracts using single-molecule and...
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| Publicado no: | Genes Dev |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7608748/ https://ncbi.nlm.nih.gov/pubmed/32943574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.339739.120 |
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