The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

Suppressor of Cytokine Signaling-1 (SOCS-1) is an essential physiological inhibitor of IFN-γ signaling. Mice lacking this gene die in the early postnatal period from a disease characterized by hyperresponsiveness to endogenous IFN-γ. The SOCS box is a C-terminal domain shared with over 30 other prot...

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Main Authors: Zhang, Jian-Guo, Metcalf, Donald, Rakar, Steven, Asimakis, Maria, Greenhalgh, Christopher J., Willson, Tracy A., Starr, Robyn, Nicholson, Sandra E., Carter, Wendy, Alexander, Warren S., Hilton, Douglas J., Nicola, Nicos A.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2001
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC60858/
https://ncbi.nlm.nih.gov/pubmed/11606785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231486498
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