The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and they act as...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., Moritz, Robert L., Cary, Dale, Richardson, Rachael, Hausmann, George, Kile, Benjamin T., Kent, Stephen B. H., Alexander, Warren S., Metcalf, Donald, Hilton, Douglas J., Nicola, Nicos A., Baca, Manuel
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1999
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26738/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10051596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.5.2071
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