The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and they act as...

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Detalhes bibliográficos
Main Authors: Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., Moritz, Robert L., Cary, Dale, Richardson, Rachael, Hausmann, George, Kile, Benjamin T., Kent, Stephen B. H., Alexander, Warren S., Metcalf, Donald, Hilton, Douglas J., Nicola, Nicos A., Baca, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC26738/
https://ncbi.nlm.nih.gov/pubmed/10051596
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