The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors of several cytokine signal transduction pathways. Their expression is induced by cytokine activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and they act as...

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Bibliografske podrobnosti
Main Authors: Zhang, Jian-Guo, Farley, Alison, Nicholson, Sandra E., Willson, Tracy A., Zugaro, Lisa M., Simpson, Richard J., Moritz, Robert L., Cary, Dale, Richardson, Rachael, Hausmann, George, Kile, Benjamin T., Kent, Stephen B. H., Alexander, Warren S., Metcalf, Donald, Hilton, Douglas J., Nicola, Nicos A., Baca, Manuel
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC26738/
https://ncbi.nlm.nih.gov/pubmed/10051596
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