Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among others, the common receptor subunit gp130. The SH2 domain of SOCS-3 has been shown to be essential for this inhibitory activity, and we have...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, Silva, Anabel, Asimakis, Maria, Farley, Alison, Nash, Andrew D., Metcalf, Donald, Hilton, Douglas J., Nicola, Nicos A., Baca, Manuel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18633/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10829066/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100135197
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