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The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
Suppressor of Cytokine Signaling-1 (SOCS-1) is an essential physiological inhibitor of IFN-γ signaling. Mice lacking this gene die in the early postnatal period from a disease characterized by hyperresponsiveness to endogenous IFN-γ. The SOCS box is a C-terminal domain shared with over 30 other prot...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC60858/ https://ncbi.nlm.nih.gov/pubmed/11606785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.231486498 |
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