A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses

To what extent immune responses against the gut flora are compartmentalized within mucosal tissues in homeostatic conditions remains a much-debated issue. We describe here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM(+) B cells in spl...

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Vydáno v:J Exp Med
Hlavní autoři: Le Gallou, Simon, Zhou, Zhicheng, Thai, Lan-Huong, Fritzen, Remi, de los Aires, Alba Verge, Mégret, Jérôme, Yu, Philipp, Kitamura, Daisuke, Bille, Emmanuelle, Tros, Fabiola, Nassif, Xavier, Charbit, Alain, Weller, Sandra, Weill, Jean-Claude, Reynaud, Claude-Agnès
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080908/
https://ncbi.nlm.nih.gov/pubmed/29959173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180977
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