A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses

To what extent immune responses against the gut flora are compartmentalized within mucosal tissues in homeostatic conditions remains a much-debated issue. We describe here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM(+) B cells in spl...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Le Gallou, Simon, Zhou, Zhicheng, Thai, Lan-Huong, Fritzen, Remi, de los Aires, Alba Verge, Mégret, Jérôme, Yu, Philipp, Kitamura, Daisuke, Bille, Emmanuelle, Tros, Fabiola, Nassif, Xavier, Charbit, Alain, Weller, Sandra, Weill, Jean-Claude, Reynaud, Claude-Agnès
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080908/
https://ncbi.nlm.nih.gov/pubmed/29959173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180977
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