A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses

To what extent immune responses against the gut flora are compartmentalized within mucosal tissues in homeostatic conditions remains a much-debated issue. We describe here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM(+) B cells in spl...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Le Gallou, Simon, Zhou, Zhicheng, Thai, Lan-Huong, Fritzen, Remi, de los Aires, Alba Verge, Mégret, Jérôme, Yu, Philipp, Kitamura, Daisuke, Bille, Emmanuelle, Tros, Fabiola, Nassif, Xavier, Charbit, Alain, Weller, Sandra, Weill, Jean-Claude, Reynaud, Claude-Agnès
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080908/
https://ncbi.nlm.nih.gov/pubmed/29959173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180977
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