T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens

Marginal zone (MZ) B cells are one of the main actors of T-independent (TI) responses in mice. To identify the B cell subset(s) involved in such responses in humans, we vaccinated healthy individuals with Pneumovax, a model TI vaccine. By high-throughput repertoire sequencing of plasma cells (PCs) i...

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Dettagli Bibliografici
Pubblicato in:Sci Immunol
Autori principali: Weller, Sandra, Sterlin, Delphine, Fadeev, Tatiana, Coignard, Eva, de los Aires, Alba Verge, Goetz, Clara, Fritzen, Rémi, Bahuaud, Mathilde, Batteux, Frederic, Gorochov, Guy, Weill, Jean-Claude, Reynaud, Claude-Agnès
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2023
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614366/
https://ncbi.nlm.nih.gov/pubmed/36706172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.ade1413
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