Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

The human peripheral B cell compartment displays a large population of IgM(+)IgD(+)CD27(+) “memory” B cell carrying a mutated Ig receptor. We show here, by phenotypic analysis, CDR3 spectratyping during a T-independent response and gene expression profiling of the different blood and splenic B cell...

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Main Authors: Weller, Sandra, Braun, Moritz C., Tan, Bruce K., Rosenwald, Andreas, Cordier, Corinne, Conley, Mary Ellen, Plebani, Alessandro, Kumararatne, Dinakhanta S., Bonnet, Damien, Tournilhac, Olivier, Tchernia, Gil, Steiniger, Birte, Staudt, Louis M., Casanova, Jean-Laurent, Reynaud, Claude-Agnès, Weill, Jean-Claude
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2590648/
https://ncbi.nlm.nih.gov/pubmed/15191950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-01-0346
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