Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines

Metformin is currently considered as a promising anticancer agent in addition to its anti-diabetic effect. To better individualize metformin therapy and explore novel molecular mechanisms in cancer treatment, we conducted a pharmacogenomic study using 266 lymphoblastoid cell lines (LCLs). Metformin...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Niu, Nifang, Liu, Tongzheng, Cairns, Junmei, Ly, Reynold C., Tan, Xianglin, Deng, Min, Fridley, Brooke L., Kalari, Krishna R., Abo, Ryan P., Jenkins, Gregory, Batzler, Anthony, Carlson, Erin E., Barman, Poulami, Moran, Sebastian, Heyn, Holger, Esteller, Manel, Wang, Liewei
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Association Studies Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078562/
https://ncbi.nlm.nih.gov/pubmed/28173075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw301
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