Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines

Metformin is currently considered as a promising anticancer agent in addition to its anti-diabetic effect. To better individualize metformin therapy and explore novel molecular mechanisms in cancer treatment, we conducted a pharmacogenomic study using 266 lymphoblastoid cell lines (LCLs). Metformin...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Niu, Nifang, Liu, Tongzheng, Cairns, Junmei, Ly, Reynold C., Tan, Xianglin, Deng, Min, Fridley, Brooke L., Kalari, Krishna R., Abo, Ryan P., Jenkins, Gregory, Batzler, Anthony, Carlson, Erin E., Barman, Poulami, Moran, Sebastian, Heyn, Holger, Esteller, Manel, Wang, Liewei
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6078562/
https://ncbi.nlm.nih.gov/pubmed/28173075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw301
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