HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins

We isolated a temperature-sensitive mutant, hrd4–1, deficient in ER-associated degradation (ERAD). The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, our analysis revealed that HRD4/NPL4 is requi...

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Detalhes bibliográficos

Publicado no:	Mol Biol Cell
Principais autores:	Bays, Nathan W., Wilhovsky, Sharon K., Goradia, Ami, Hodgkiss-Harlow, Kelley, Hampton, Randolph Y.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Cell Biology 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.12.12.4114
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