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HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins
We isolated a temperature-sensitive mutant, hrd4–1, deficient in ER-associated degradation (ERAD). The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, our analysis revealed that HRD4/NPL4 is requi...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Cell Biology
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC60780/ https://ncbi.nlm.nih.gov/pubmed/11739805 |
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