HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins
We isolated a temperature-sensitive mutant, hrd4–1, deficient in ER-associated degradation (ERAD). The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, our analysis revealed that HRD4/NPL4 is requi...
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| Vydáno v: | Mol Biol Cell |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Cell Biology
2001
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739805/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.12.12.4114 |
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