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Sequence Determinants for Regulated Degradation of Yeast 3-Hydroxy-3-Methylglutaryl-CoA Reductase, an Integral Endoplasmic Reticulum Membrane Protein

The degradation rate of 3-hydroxy-3-methylglutaryl CoA reductase (HMG-R), a key enzyme of the mevalonate pathway, is regulated through a feedback mechanism by the mevalonate pathway. To discover the intrinsic determinants involved in the regulated degradation of the yeast HMG-R isozyme Hmg2p, we rep...

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Detalhes bibliográficos
Main Authors: Gardner, Richard, Cronin, Stephen, Leader, Benjamin, Rine, Jasper, Hampton, Randolph
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC25534/
https://ncbi.nlm.nih.gov/pubmed/9725915
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