Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

The treatment of ischemic strokes is limited to prophylactic agents that block the coagulation cascade. Here, we show that cholesterol-lowering agents, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors, protect against cerebral injury by a previously unidentified mechanism involving the sele...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Endres, Matthias, Laufs, Ulrich, Huang, Zhihong, Nakamura, Tadashi, Huang, Paul, Moskowitz, Michael A., Liao, James K.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21171/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671773/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8880
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