HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins

We isolated a temperature-sensitive mutant, hrd4–1, deficient in ER-associated degradation (ERAD). The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, our analysis revealed that HRD4/NPL4 is requi...

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Main Authors: Bays, Nathan W., Wilhovsky, Sharon K., Goradia, Ami, Hodgkiss-Harlow, Kelley, Hampton, Randolph Y.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC60780/
https://ncbi.nlm.nih.gov/pubmed/11739805
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