Dependence of Endoplasmic Reticulum-associated Degradation on the Peptide Binding Domain and Concentration of BiP

ER-associated degradation (ERAD) removes defective and mis-folded proteins from the eukaryotic secretory pathway, but mutations in the ER lumenal Hsp70, BiP/Kar2p, compromise ERAD efficiency in yeast. Because attenuation of ERAD activates the UPR, we screened for kar2 mutants in which the unfolded p...

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Detalhes bibliográficos

Publicado no:	Mol Biol Cell
Principais autores:	Kabani, Mehdi, Kelley, Stephanie S., Morrow, Michael W., Montgomery, Diana L., Sivendran, Renuka, Rose, Mark D., Gierasch, Lila M., Brodsky, Jeffrey L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Cell Biology 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC181579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12925775/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E02-12-0847
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