Dependence of Endoplasmic Reticulum-associated Degradation on the Peptide Binding Domain and Concentration of BiP
ER-associated degradation (ERAD) removes defective and mis-folded proteins from the eukaryotic secretory pathway, but mutations in the ER lumenal Hsp70, BiP/Kar2p, compromise ERAD efficiency in yeast. Because attenuation of ERAD activates the UPR, we screened for kar2 mutants in which the unfolded p...
Збережено в:
| Опубліковано в:: | Mol Biol Cell |
|---|---|
| Автори: | , , , , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Society for Cell Biology
2003
|
| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC181579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12925775/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E02-12-0847 |
| Теги: |
Немає тегів, Будьте першим, хто поставить тег для цього запису!
|