The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Engineering T cells with chimeric antigen receptors (CARs) is an effective method for directing T cells to attack tumors, but may cause adverse side effects such as the potentially lethal cytokine release syndrome. Here the authors show that the T cell antigen coupler (TAC), a chimeric receptor that...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Helsen, Christopher W., Hammill, Joanne A., Lau, Vivian W. C., Mwawasi, Kenneth A., Afsahi, Arya, Bezverbnaya, Ksenia, Newhook, Lisa, Hayes, Danielle L., Aarts, Craig, Bojovic, Bojana, Denisova, Galina F., Kwiecien, Jacek M., Brain, Ian, Derocher, Heather, Milne, Katy, Nelson, Brad H., Bramson, Jonathan L.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076291/
https://ncbi.nlm.nih.gov/pubmed/30076299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05395-y
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