The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Engineering T cells with chimeric antigen receptors (CARs) is an effective method for directing T cells to attack tumors, but may cause adverse side effects such as the potentially lethal cytokine release syndrome. Here the authors show that the T cell antigen coupler (TAC), a chimeric receptor that...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Helsen, Christopher W., Hammill, Joanne A., Lau, Vivian W. C., Mwawasi, Kenneth A., Afsahi, Arya, Bezverbnaya, Ksenia, Newhook, Lisa, Hayes, Danielle L., Aarts, Craig, Bojovic, Bojana, Denisova, Galina F., Kwiecien, Jacek M., Brain, Ian, Derocher, Heather, Milne, Katy, Nelson, Brad H., Bramson, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076291/
https://ncbi.nlm.nih.gov/pubmed/30076299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05395-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados