A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity

Tumor-targeted chimeric antigen receptor (CAR)-engineered T lymphocytes (CAR-T cells) have demonstrated striking clinical success, but their use has been associated with a constellation of toxicities. A better understanding of the pathogenesis of these toxicities is required to improve the safety pr...

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Vydáno v:Mol Ther Oncolytics
Hlavní autoři: Hammill, Joanne A., Kwiecien, Jacek M., Dvorkin-Gheva, Anna, Lau, Vivian W.C., Baker, Christopher, Wu, Ying, Bezverbnaya, Ksenia, Aarts, Craig, Heslen, Christopher W., Denisova, Galina F., Derocher, Heather, Milne, Katy, Nelson, Brad H., Bramson, Jonathan L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191649/
https://ncbi.nlm.nih.gov/pubmed/32368616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.04.001
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