Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

Despite the remarkable success of chimeric antigen receptor (CAR)-T cells against hematologic malignancies, severe off-tumor effects have constrained their use against solid tumors. Recently, CAR-engineered natural killer (NK) cells have emerged as an effective and safe alternative. Here, we demonst...

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Vydáno v:iScience
Hlavní autoři: Portillo, Ana L., Hogg, Richard, Poznanski, Sophie M., Rojas, Eduardo A., Cashell, Niamh J., Hammill, Joanne A., Chew, Marianne V., Shenouda, Mira M., Ritchie, Tyrah M., Cao, Quynh T., Hirota, Jeremy A., Dhesy-Thind, Sukhbinder, Bramson, Jonathan L., Ashkar, Ali A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193615/
https://ncbi.nlm.nih.gov/pubmed/34159300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102619
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