T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice

Ligands for the NKG2D receptor are overexpressed on tumors, making them interesting immunotherapy targets. To assess the tumoricidal properties of T cells directed to attack NKG2D ligands, we engineered murine T cells with two distinct NKG2D-based chimeric antigen receptors (CARs): (i) a fusion betw...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: VanSeggelen, Heather, Hammill, Joanne A, Dvorkin-Gheva, Anna, Tantalo, Daniela GM, Kwiecien, Jacek M, Denisova, Galina F, Rabinovich, Brian, Wan, Yonghong, Bramson, Jonathan L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817919/
https://ncbi.nlm.nih.gov/pubmed/26122933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.119
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