T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice

Ligands for the NKG2D receptor are overexpressed on tumors, making them interesting immunotherapy targets. To assess the tumoricidal properties of T cells directed to attack NKG2D ligands, we engineered murine T cells with two distinct NKG2D-based chimeric antigen receptors (CARs): (i) a fusion betw...

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Publicado en:Mol Ther
Main Authors: VanSeggelen, Heather, Hammill, Joanne A, Dvorkin-Gheva, Anna, Tantalo, Daniela GM, Kwiecien, Jacek M, Denisova, Galina F, Rabinovich, Brian, Wan, Yonghong, Bramson, Jonathan L
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817919/
https://ncbi.nlm.nih.gov/pubmed/26122933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.119
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