T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice

Ligands for the NKG2D receptor are overexpressed on tumors, making them interesting immunotherapy targets. To assess the tumoricidal properties of T cells directed to attack NKG2D ligands, we engineered murine T cells with two distinct NKG2D-based chimeric antigen receptors (CARs): (i) a fusion betw...

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發表在:Mol Ther
Main Authors: VanSeggelen, Heather, Hammill, Joanne A, Dvorkin-Gheva, Anna, Tantalo, Daniela GM, Kwiecien, Jacek M, Denisova, Galina F, Rabinovich, Brian, Wan, Yonghong, Bramson, Jonathan L
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817919/
https://ncbi.nlm.nih.gov/pubmed/26122933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.119
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