Combined mTOR Inhibition and OX40 Agonism Enhances CD8(+) T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines

The memory CD8(+) T cell population elicited by immunization with recombinant human adenovirus serotype 5 (rHuAd5) vaccines is composed primarily of effector and effector memory cells (T(EM)) with limited polyfunctionality. In this study, we investigated whether treatment with immunomodulators could...

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Detalhes bibliográficos
Main Authors: Bassett, Jennifer D, Swift, Stephanie L, VanSeggelen, Heather, Hammill, Joanne A, McGray, AJ Robert, Evelegh, Carole, Wan, Yonghong, Bramson, Jonathan L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321597/
https://ncbi.nlm.nih.gov/pubmed/22186790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.281
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