The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity

Engineering T cells with chimeric antigen receptors (CARs) is an effective method for directing T cells to attack tumors, but may cause adverse side effects such as the potentially lethal cytokine release syndrome. Here the authors show that the T cell antigen coupler (TAC), a chimeric receptor that...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Helsen, Christopher W., Hammill, Joanne A., Lau, Vivian W. C., Mwawasi, Kenneth A., Afsahi, Arya, Bezverbnaya, Ksenia, Newhook, Lisa, Hayes, Danielle L., Aarts, Craig, Bojovic, Bojana, Denisova, Galina F., Kwiecien, Jacek M., Brain, Ian, Derocher, Heather, Milne, Katy, Nelson, Brad H., Bramson, Jonathan L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076291/
https://ncbi.nlm.nih.gov/pubmed/30076299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05395-y
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