Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer

Monoclonal antibodies (mAbs) are used as targeted therapies against cancers. These mAbs kill cancer cells via various mechanisms of actions. In this study, human embryonic stem cells (hESCs) was used as the immunogen to generate a panel of antibodies. From this panel of mAbs, A19 was found to bind b...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Tan, Heng Liang, Yong, Charlene, Tan, Bao Zhu, Fong, Wey Jia, Padmanabhan, Jayanthi, Chin, Angela, Ding, Vanessa, Lau, Ally, Zheng, Lu, Bi, Xuezhi, Yang, Yuansheng, Choo, Andre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072701/
https://ncbi.nlm.nih.gov/pubmed/30072783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30070-z
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