Conservation of oncofetal antigens on human embryonic stem cells enables discovery of monoclonal antibodies against cancer

Monoclonal antibodies (mAbs) are used as targeted therapies against cancers. These mAbs kill cancer cells via various mechanisms of actions. In this study, human embryonic stem cells (hESCs) was used as the immunogen to generate a panel of antibodies. From this panel of mAbs, A19 was found to bind b...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tan, Heng Liang, Yong, Charlene, Tan, Bao Zhu, Fong, Wey Jia, Padmanabhan, Jayanthi, Chin, Angela, Ding, Vanessa, Lau, Ally, Zheng, Lu, Bi, Xuezhi, Yang, Yuansheng, Choo, Andre
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072701/
https://ncbi.nlm.nih.gov/pubmed/30072783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30070-z
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