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In vivo surveillance and elimination of teratoma‐forming human embryonic stem cells with monoclonal antibody 2448 targeting annexin A2

This study describes the use of a previously reported chimerised monoclonal antibody (mAb), ch2448, to kill human embryonic stem cells (hESCs) in vivo and prevent or delay the formation of teratomas. ch2448 was raised against hESCs and was previously shown to effectively kill ovarian and breast canc...

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Detalhes bibliográficos
Publicado no:Biotechnol Bioeng
Main Authors: Tan, Heng Liang, Tan, Bao Zhu, Goh, Winfred Xi Tai, Cua, Simeon, Choo, Andre
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790577/
https://ncbi.nlm.nih.gov/pubmed/31388993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27135
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