Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells

Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells. Four 2A peptides derived from the foot-and-mouth disease virus (F2A), equine rhinitis...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Chng, Jake, Wang, Tianhua, Nian, Rui, Lau, Ally, Hoi, Kong Meng, Ho, Steven CL, Gagnon, Peter, Bi, Xuezhi, Yang, Yuansheng
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622431/
https://ncbi.nlm.nih.gov/pubmed/25621616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1008351
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