Prospective randomized biomarker study of metformin and lifestyle intervention for prevention in obese women at increased risk for endometrial cancer

Obesity increases risk of endometrial cancer through dysregulation of estrogen and insulin signaling. The primary aim of this study was to evaluate the impact of metformin or lifestyle intervention on endometrial proliferation in postmenopausal obese women. Secondary aims included evaluating obesity...

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Veröffentlicht in:Cancer Prev Res (Phila)
Hauptverfasser: Yates, Melinda S., Coletta, Adriana M., Zhang, Qian, Schmandt, Rosemarie E., Medepalli, Meena, Nebgen, Denise, Soletsky, Beth, Milbourne, Andrea, Levy, Erma, Fellman, Bryan, Urbauer, Diana, Yuan, Ying, Broaddus, Russell R., Basen-Engquist, Karen, Lu, Karen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072574/
https://ncbi.nlm.nih.gov/pubmed/29716897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-17-0398
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