Prospective evaluation of the molecular effects of metformin on the endometrium in women with newly diagnosed endometrial cancer: A window of opportunity study

OBJECTIVE: Metformin reduces cancer incidence and improves overall survival in diabetic patients. In preclinical studies, metformin decreases endometrial cancer (EC) cell growth by activation of AMPK/mTOR inhibition. We sought to determine the effects of metformin on serum/tumor biomarkers in women...

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Udgivet i:Gynecol Oncol
Main Authors: Soliman, Pamela T., Zhang, Qian, Broaddus, Russell R., Westin, Shannon N., Iglesias, David, Munsell, Mark F., Schmandt, Rosemarie, Yates, Melinda, Ramondetta, Lois, Lu, Karen H.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5116402/
https://ncbi.nlm.nih.gov/pubmed/27745917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2016.10.011
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