CGRRF1 as a novel biomarker of tissue response to metformin in the context of obesity

OBJECTIVE: Obesity-associated hyperestrogenism and hyperinsulinemia contribute significantly to the pathogenesis of endometrial cancer. We recently demonstrated that metformin, a drug long used for treatment of type 2 diabetes, attenuates both insulin- and estrogen-mediated proliferative signaling i...

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Main Authors: Zhang, Qian, Schmandt, Rosemarie, Celestino, Joseph, McCampbell, Adrienne, Yates, Melinda S., Urbauer, Diana L., Broaddus, Russell R., Loose, David S., Shipley, Gregory L., Lu, Karen H.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077340/
https://ncbi.nlm.nih.gov/pubmed/24680596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2013.12.006
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