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Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M(1) and M(2)
A set of hybrid compounds composed of the fragment of allosteric modulators of the muscarinic receptor, i.e. W84 and naphmethonium, and the well-known AChE inhibitor tacrine on the one hand, and the skeletons of the orthosteric muscarinic agonists, iperoxo and isox, on the other hand, were synthesiz...
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| Pubblicato in: | Medchemcomm |
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| Autori principali: | , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6072511/ https://ncbi.nlm.nih.gov/pubmed/30108847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00149e |
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