Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M(1) and M(2)

A set of hybrid compounds composed of the fragment of allosteric modulators of the muscarinic receptor, i.e. W84 and naphmethonium, and the well-known AChE inhibitor tacrine on the one hand, and the skeletons of the orthosteric muscarinic agonists, iperoxo and isox, on the other hand, were synthesiz...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Messerer, Regina, Dallanoce, Clelia, Matera, Carlo, Wehle, Sarah, Flammini, Lisa, Chirinda, Brian, Bock, Andreas, Irmen, Matthias, Tränkle, Christian, Barocelli, Elisabetta, Decker, Michael, Sotriffer, Christoph, De Amici, Marco, Holzgrabe, Ulrike
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072511/
https://ncbi.nlm.nih.gov/pubmed/30108847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00149e
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