Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor

G protein-coupled receptors constitute the largest family of membrane receptors and modulate almost every physiological process in humans. Binding of agonists to G protein-coupled receptors induces a shift from inactive to active receptor conformations. Biophysical studies of the dynamic equilibrium...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bock, Andreas, Bermudez, Marcel, Krebs, Fabian, Matera, Carlo, Chirinda, Brian, Sydow, Dominique, Dallanoce, Clelia, Holzgrabe, Ulrike, De Amici, Marco, Lohse, Martin J., Wolber, Gerhard, Mohr, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965584/
https://ncbi.nlm.nih.gov/pubmed/27298318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.735431
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