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Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor
G protein-coupled receptors constitute the largest family of membrane receptors and modulate almost every physiological process in humans. Binding of agonists to G protein-coupled receptors induces a shift from inactive to active receptor conformations. Biophysical studies of the dynamic equilibrium...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4965584/ https://ncbi.nlm.nih.gov/pubmed/27298318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.735431 |
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