Effect of N-1 arylation of monastrol on kinesin Eg5 inhibition in glioma cell lines

An original and focused library of two sets of dihydropyrimidin-2-thiones (DHPMs) substituted with N-1 aryl groups derived from monastrol was designed and synthesized in order to discover a more effective Eg5 ligand than the template. Based on molecular docking studies, four ligands were selected to...

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Publicado en:Medchemcomm
Autores principales: Gonçalves, Itamar Luís, Rockenbach, Liliana, das Neves, Gustavo Machado, Göethel, Gabriela, Nascimento, Fabiana, Porto Kagami, Luciano, Figueiró, Fabrício, Oliveira de Azambuja, Gabriel, de Fraga Dias, Amanda, Amaro, Andressa, de Souza, Lauro Mera, da Rocha Pitta, Ivan, Avila, Daiana Silva, Kawano, Daniel Fábio, Garcia, Solange Cristina, Battastini, Ana Maria Oliveira, Eifler-Lima, Vera Lucia
Formato: Artigo
Lenguaje:Inglês
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072436/
https://ncbi.nlm.nih.gov/pubmed/30108989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00095f
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