Effect of N-1 arylation of monastrol on kinesin Eg5 inhibition in glioma cell lines

An original and focused library of two sets of dihydropyrimidin-2-thiones (DHPMs) substituted with N-1 aryl groups derived from monastrol was designed and synthesized in order to discover a more effective Eg5 ligand than the template. Based on molecular docking studies, four ligands were selected to...

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Publicado no:Medchemcomm
Main Authors: Gonçalves, Itamar Luís, Rockenbach, Liliana, das Neves, Gustavo Machado, Göethel, Gabriela, Nascimento, Fabiana, Porto Kagami, Luciano, Figueiró, Fabrício, Oliveira de Azambuja, Gabriel, de Fraga Dias, Amanda, Amaro, Andressa, de Souza, Lauro Mera, da Rocha Pitta, Ivan, Avila, Daiana Silva, Kawano, Daniel Fábio, Garcia, Solange Cristina, Battastini, Ana Maria Oliveira, Eifler-Lima, Vera Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6072436/
https://ncbi.nlm.nih.gov/pubmed/30108989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00095f
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