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A structural model for monastrol inhibition of dimeric kinesin Eg5
Eg5 or KSP is a homotetrameric Kinesin-5 involved in centrosome separation and assembly of the bipolar mitotic spindle. Analytical gel filtration of purified protein and cryo-electron microscopy (cryo-EM) of unidirectional shadowed microtubule–Eg5 complexes have been used to identify the stable dime...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1462975/ https://ncbi.nlm.nih.gov/pubmed/16642039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601108 |
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