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A structural model for monastrol inhibition of dimeric kinesin Eg5

Eg5 or KSP is a homotetrameric Kinesin-5 involved in centrosome separation and assembly of the bipolar mitotic spindle. Analytical gel filtration of purified protein and cryo-electron microscopy (cryo-EM) of unidirectional shadowed microtubule–Eg5 complexes have been used to identify the stable dime...

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Autores principales: Krzysiak, Troy C, Wendt, Thomas, Sproul, Lisa R, Tittmann, Peter, Gross, Heinz, Gilbert, Susan P, Hoenger, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462975/
https://ncbi.nlm.nih.gov/pubmed/16642039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601108
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