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Monastrol Inhibition of the Mitotic Kinesin Eg5
Monastrol is a small, cell-permeable molecule that arrests cells in mitosis by specifically inhibiting Eg5, a member of the Kinesin-5 family. We have used steady-state and presteady-state kinetics as well as equilibrium binding approaches to define the mechanistic basis of S-monastrol inhibition of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1356610/ https://ncbi.nlm.nih.gov/pubmed/15665380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M413140200 |
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