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Monastrol Inhibition of the Mitotic Kinesin Eg5

Monastrol is a small, cell-permeable molecule that arrests cells in mitosis by specifically inhibiting Eg5, a member of the Kinesin-5 family. We have used steady-state and presteady-state kinetics as well as equilibrium binding approaches to define the mechanistic basis of S-monastrol inhibition of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cochran, Jared C., Gatial, Joseph E., Kapoor, Tarun M., Gilbert, Susan P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356610/
https://ncbi.nlm.nih.gov/pubmed/15665380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M413140200
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